This was one of the best games I ever ran.
I ran some years back a game where 10,000 people were on a massive ship heading to colonize Mars. And a small batch of fueding WoD Vampire sorts got onboard. At the outset of the game I told people there would be murder and mayhem, and player death would mean you were out of the game. If you failed to show up for a session your character would be killed. I started with 15 people (it was at a gaming store) and by session three I was down to six people. When the finale happened, only two players survived. All of the original vampires were dead, and all but one of the vampirized players were dead.
Since the ship had tons of rad shielding, vampires never needed to sleep. The ship rotated around a giant axis, and the inside had parks and stuff. The inner core was zero/micro gravity.
None of the vampires were managed to be killed via brute force. They died because a few smart players used their brains. A partial role call of killed vampires:
1. A vampire-hunter turned vampie was suspected by a smart player. The smart player boobytrapped the improvised flamethrower he gave to the vampiric vampire hunter. When the new bad guy turned on his mates... kaboom!
2. The big boss vampire was injured badly while killing three players. The player Unitarian Minister boarded the pedicab ambulance and while the medics were opening their veins for their master, he opened an oxygen tank and managed to get a spark off. Kaboom!
The game also created some unforgettabl quotes:
1. I know! Lets split up so we can cover more ground! (Several stupid players took this advice and got promptly killed)
2. Lets sneak off from the rest so then we can surprise them later! (Two players died together this way)
3. I reprogram the video camera to fire a laser beam! (Said by a guy who was a techie-poser. We all laughed)
4. How do Vampires react to hard vacuum?
FYI, Tony, creator of Capes, was the surviving vampire.
One day I'll run a sequel. I promise. Or maybe I could turn it into a convention game? Hrm...